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Article

Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

International journal of molecular sciences - 31 Dec 2014

Reiner Anton, Heldt Scott A, Presley Chaela S, Guley Natalie H, Elberger Andrea J, Deng Yunping, D'Surney Lauren, Rogers Joshua T, Ferrell Jessica, Bu Wei, Del Mar Nobel, Honig Marcia G, Gurley Steven N, Moore Bob M

Abstract excerpt

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50-60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be...

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Identifiers

PMID: 25561230
DOI: 10.3390/ijms16010758
PMCID: PMC4307274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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