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Article

The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis.

Journal of bacteriology - 1 Dec 2002

Kojima Ikuo, Kasuga Kano, Kobayashi Masayuki, Fukasawa Akira, Mizuno Satoshi, Arisawa Akira, Akagawa Hisayoshi

Abstract excerpt

The occurrence of pleiotropic mutants that are defective in both antibiotic production and aerial mycelium formation is peculiar to streptomycetes. Pleiotropic mutant KSB was isolated from wild-type Streptomyces kasugaensis A1R6, which produces kasugamycin, an antifungal aminoglycoside antibiotic. A 9.3-kb DNA fragment was cloned from the chromosomal DNA of strain A1R6 by complementary restoration of kasugamycin...

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Identifiers

PMID: 12426327
DOI: 10.1128/JB.184.23.6417-6423.2002
PMCID: PMC135429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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