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Article

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Open biology - 23 Oct 2013

Makitrynskyy Roman, Ostash Bohdan, Tsypik Olga, Rebets Yuriy, Doud Emma, Meredith Timothy, Luzhetskyy Andriy, Bechthold Andreas, Walker Suzanne, Fedorenko Victor

Abstract excerpt

Unlike the majority of actinomycete secondary metabolic pathways, the biosynthesis of peptidoglycan glycosyltransferase inhibitor moenomycin in Streptomyces ghanaensis does not involve any cluster-situated regulators (CSRs). This raises questions about the regulatory signals that initiate and sustain moenomycin production. We now show that three pleiotropic regulatory genes for Streptomyces morphogenesis and...

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PMID: 24153004
DOI: 10.1098/rsob.130121
PMCID: PMC3814723

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Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.PMID 24153004Read ↗

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