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Article

Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2006

Yanai Koji, Murakami Takeshi, Bibb Mervyn

Abstract excerpt

Streptomyces kanamyceticus 12-6 is a derivative of the wild-type strain developed for industrial kanamycin (Km) production. Southern analysis and DNA sequencing revealed amplification of a large genomic segment including the entire Km biosynthetic gene cluster in the chromosome of strain 12-6. At 145 kb, the amplifiable unit of DNA (AUD) is the largest AUD reported in Streptomyces. Striking repetitive DNA...

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Identifiers

PMID: 16766657
DOI: 10.1073/pnas.0603251103
PMCID: PMC1475798

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