Article
The role of licA phase variation in the pathogenesis of invasive disease by Haemophilus influenzae type b.
FEMS immunology and medical microbiology - 15 Nov 2002
Humphries Holly E, High Nicola J
Abstract excerpt
LicA encodes the enzyme phosphorylcholine kinase which catalyses the incorporation of phosphorylcholine (ChoP) into H. influenzae LPS. Expression of this gene is subject to phase variation, resulting in the spontaneous loss, or gain of phosphorylcholine (ChoP)-decorated LPS structures. To investigate the role of this phenomenon in the pathogenesis of invasive disease an H. influenzae mutant was constructed which...
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