Article
The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing.
Molecular microbiology - 1 Jan 2000
Lysenko E, Richards J C, Cox A D, Stewart A, Martin A, Kapoor M, Weiser J N
Abstract excerpt
The lic1 locus of Haemophilus influenzae controls the incorporation of environmental choline into lipopolysaccharide (LPS) as phosphorylcholine (ChoP) as well as the phase variation of this structure. ChoP is the target of an acute phase reactant in serum, C-reactive protein (CRP), which mediates killing through the activation of complement when bound to the organism. Structural analysis of the oligosaccharide...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- C-Reactive Protein
- Carbohydrate Sequence
- DNA Primers
- Haemophilus influenzae
- Lipopolysaccharides
- Molecular Sequence Data
- Mutation