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Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae

1 Mar 2012

Abstract excerpt

The human pathogen Haemophilus influenzae has the ability to quickly adapt to different host environments through phase variation of multiple structures on its lipooligosaccharide (LPS), including phosphorylcholine (ChoP). During colonization with H. influenzae, there is a selection for ChoP+ phase variants. In a murine model of nasopharyngeal colonization, this selection is lost in the absence of adaptive...

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PMID: 22396641
DOI: 10.1371/journal.ppat.1002521

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