Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phase variation of lic1A, lic2A and lic3A in colonization of the nasopharynx, bloodstream and cerebrospinal fluid by Haemophilus influenzae type b.

Microbiology (Reading, England) - 1 Nov 1999

Hosking Sarah L, Craig Jane E, High Nicola J

Abstract excerpt

The role of phase variation of lic1A, lic2A and lic3A in the ability of Haemophilus influenzae type b to colonize the nasopharynx, bloodstream and cerebrospinal fluid (CSF) of infants was investigated. This was achieved by using PCR to determine the number of 5'-CAAT-3' repeats present in each gene, which is indicative of whether each ORF can be expressed. Multiple PCR products of different intensities were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Bacteremia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Haemophilus Infections

Share to Haemophilus influenzae

Share to Nasopharynx

Share to Rats, Sprague-Dawley

Share to Terminal Repeat Sequences

Source

Identifiers

PMID: 10589708
DOI: 10.1099/00221287-145-11-3005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phase variation of lic1A, lic2A and lic3A in colonization of the nasopharynx, bloodstream and cerebrospinal fluid by Haemophilus influenzae type b.PMID 10589708Read ↗

The role of licA phase variation in the pathogenesis of invasive disease by Haemophilus influenzae type b.Semantic proximity Read ↗

Tandem repeats of the tetramer 5'-CAAT-3' present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae.Semantic proximity Read ↗

Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.Semantic proximity Read ↗

Use of chromosomal gene fusions to investigate the role of repetitive DNA in regulation of genes involved in lipopolysaccharide biosynthesis in Haemophilus influenzae.Semantic proximity Read ↗

Nontypable Haemophilus influenzae Displays a Prevalent Surface Structure Molecular Pattern in Clinical IsolatesSemantic proximity Read ↗

Adaptation of <i>Haemophilus influenzae</i> to acquired and innate humoral immunity based on phase variation of lipopolysaccharideSemantic proximity Read ↗

Identification of the functional initiation codons of a phase-variable gene of Haemophilus influenzae, lic2A, with the potential for differential expression.Semantic proximity Read ↗

The effect of mutations in genes required for lipopolysaccharide synthesis on Haemophilus influenzae type b colonization of human nasopharyngeal tissue.Semantic proximity Read ↗

The role of Dam methylation in phase variation of Haemophilus influenzae genes involved in defence against phage infection.Semantic proximity Read ↗

Simple sequence repeats in Haemophilus influenzae.Semantic proximity Read ↗

Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.Semantic proximity Read ↗

Pharyngeal colonization dynamics of Haemophilus influenzae and Haemophilus haemolyticus in healthy adult carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.