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Article

Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.

Infection and immunity - 1 Oct 1990

Weiser J N, Williams A, Moxon E R

Abstract excerpt

Genes necessary for the expression and phase variation of lipopolysaccharide epitopes of a virulent Haemophilus influenzae type b isolate (RM.7004) are contained within two chromosomal loci designated lic-1 and lic-2. Mutations were introduced into both lic-1 and lic-2, and the virulence of the double mutant was compared with that of the wild type in infant rats. These mutations in RM.7004 resulted in a...

Topics

Animals
Chromosomes, Bacterial
Colony Count, Microbial
Haemophilus Infections
Haemophilus influenzae
Lipopolysaccharides
Mutation
Nasopharynx
Random Allocation
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2401571
DOI: 10.1128/iai.58.10.3455-3457.1990
PMCID: PMC313677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2401571-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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