Article
Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.
Infection and immunity - 1 Oct 1990
Weiser J N, Williams A, Moxon E R
Abstract excerpt
Genes necessary for the expression and phase variation of lipopolysaccharide epitopes of a virulent Haemophilus influenzae type b isolate (RM.7004) are contained within two chromosomal loci designated lic-1 and lic-2. Mutations were introduced into both lic-1 and lic-2, and the virulence of the double mutant was compared with that of the wild type in infant rats. These mutations in RM.7004 resulted in a...
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