Article
Characterization of the phosphocholine-substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae.
European journal of biochemistry - 1 Jun 2000
Schweda E K, Brisson J R, Alvelius G, Martin A, Weiser J N, Hood D W, Moxon E R, Richards J C
Abstract excerpt
Haemophilus influenzae expresses heterogeneous populations of short-chain lipopolysaccharide (LPS) which exhibit extensive antigenic diversity among multiple oligosaccharide epitopes. These LPS oligosaccharide epitopes can carry phosphocholine (PCho) substituents, the expression of which is subject to high frequency phase variation mediated by genes in the lic1 genetic locus. The location and site of attachment...
Topics
- Acetylation
- Carbohydrate Sequence
- Epitopes
- Haemophilus influenzae type b
- Lipopolysaccharides
- Molecular Structure
- Mutation
- Phosphorylcholine