Article
Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein.
The Journal of experimental medicine - 16 Feb 1998
Weiser J N, Pan N, McGowan K L, Musher D, Martin A, Richards J
Abstract excerpt
Haemophilus influenzae undergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on several invasive pathogens residing in the human respiratory tract. In this study, structural analysis comparing organisms with and without this epitope confirmed that va...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blood Bactericidal Activity
- C-Reactive Protein
- Epitope Mapping
- Genotype
- Haemophilus Infections
- Haemophilus influenzae
- Humans
- Immunoglobulin G
- Lipopolysaccharides
- Molecular Sequence Data
- Phosphorylcholine