Article
The role of the alarmone (p)ppGpp in sigma N competition for core RNA polymerase.
The Journal of biological chemistry - 17 Jan 2003
Laurie Andrew D, Bernardo Lisandro M D, Sze Chun Chau, Skarfstad Eleonore, Szalewska-Palasz Agnieszka, Nyström Thomas, Shingler Victoria
Abstract excerpt
Some promoters, including the DmpR-controlled sigma(N)-dependent Po promoter, are effectively rendered silent in cells lacking the nutritional alarmone (p)ppGpp. Here we demonstrate that four mutations within the housekeeping sigma(D)-factor can restore sigma(N)-dependent Po transcription in the absence of (p)ppGpp. Using both in vitro and in vivo transcription competition assays, we show that all the four...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.