Article
Properties of RNA polymerase bypass mutants: implications for the role of ppGpp and its co-factor DksA in controlling transcription dependent on sigma54.
The Journal of biological chemistry - 22 Jun 2007
Szalewska-Palasz Agnieszka, Johansson Linda U M, Bernardo Lisandro M D, Skärfstad Eleonore, Stec Ewa, Brännström Kristoffer, Shingler Victoria
Abstract excerpt
The bacterial nutritional and stress alarmone ppGpp and its co-factor DksA directly bind RNA polymerase to regulate its activity at certain sigma70-dependent promoters. A number of promoters that are dependent on alternative sigma-factors function poorly in the absence of ppGpp. These include the Pseudomonas-derived sigma54-dependent Po promoter and several other sigma54-promoters, the transcription from which is...
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