Article
Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster.
Development (Cambridge, England) - 1 Dec 2002
Dansereau David A, Lunke Martine D, Finkielsztein Ariel, Russell Michael A, Brook William J
Abstract excerpt
We describe the role of the Drosophila melanogaster hephaestus gene in wing development. We have identified several hephaestus mutations that map to a gene encoding a predicted RNA-binding protein highly related to human polypyrimidine tract binding protein and Xenopus laevis 60 kDa Vg1 mRNA-binding protein. Polypyrimidine tract binding proteins play diverse roles in RNA processing including the subcellular...
Topics
- Alleles
- Animals
- Cloning, Molecular
- DNA, Complementary
- Drosophila Proteins
- Drosophila melanogaster
- Immunohistochemistry
- Intracellular Signaling Peptides and Proteins
- Ligands
- Membrane Proteins
- Models, Biological
- Models, Genetic
- Mutagenesis, Site-Directed