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Article

Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.

PloS one - 1 Jan 2011

Wesley Cedric S, Guo Heng, Chaudhry Kanita A, Thali Markus J, Yin Jerry C, Clason Todd, Wesley Umadevi V

Abstract excerpt

Polypyrimidine Tract Binding (PTB) protein is a regulator of mRNA processing and translation. Genetic screens and studies of wing and bristle development during the post-embryonic stages of Drosophila suggest that it is a negative regulator of the Notch pathway. How PTB regulates the Notch pathway is unknown. Our studies of Drosophila embryogenesis indicate that (1) the Notch mRNA is a potential target of PTB,...

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Identifiers

PMID: 21750738
DOI: 10.1371/journal.pone.0021876
PMCID: PMC3130057

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Source receipt: pubmed, retrieved 7 Sept 2026.

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