Article
Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reduction.
PloS one - 25 Mar 2011
Choi Sung Sook, Chivers Peter T, Berg Douglas E
Abstract excerpt
BACKGROUND: Helicobacter pylori's Fur regulatory protein controls transcription of dozens of genes in response to iron availability, acidity and oxidative stress, and affects the vigor of infection and severity of disease. It is unusual among Fur family proteins in being active both when iron-loaded and iron-free. METHOLODOLGY/PRINCIPAL FINDINGS: We tested if H. pylori fur mutations could affect resistance to...
Topics
- Alleles
- Amino Acid Sequence
- Bacterial Proteins
- Binding Sites
- DNA Mutational Analysis
- Drug Resistance, Bacterial
- Epistasis, Genetic
- Gene Deletion
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genes, Regulator
- Genotype
- Helicobacter pylori