Article
Grb2 is a key mediator of helicobacter pylori CagA protein activities.
Molecular cell - 1 Oct 2002
Mimuro Hitomi, Suzuki Toshihiko, Tanaka Jiro, Asahi Momoyo, Haas Rainer, Sasakawa Chihiro
Abstract excerpt
CagA delivered from Helicobacter pylori into gastric epithelial cells undergoes tyrosine phosphorylation and induces host cell morphological changes. Here we show that CagA can interact with Grb2 both in vitro and in vivo, which results in the activation of the Ras/MEK/ERK pathway and leads to cell scattering as well as proliferation. Importantly, this ability of CagA is independent from the tyrosine...
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