Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cytomegalovirus immediate-early over protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cells

1 Jan 2003

Abstract excerpt

In human cytomegalovirus (HCMV) infection, the isolated expression of the viral immediate-early protein 2 (IE2) 86 kDa regulatory protein coincides with an up-regulation of cyclin E gene expression, both in fibroblasts and U373 cells. Since IE2 also interferes with cell-cycle progression, it is unclear whether IE2 is a genuine activator of cyclin E or whether IE2-arrested cells contain elevated levels of cyclin E...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12533700
DOI: 10.1099/vir.0.18702-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cytomegalovirus immediate-early over protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cellsPMID 12533700Read ↗

Human Cytomegalovirus 86-Kilodalton IE2 Protein Blocks Cell Cycle Progression in G 1Semantic proximity Read ↗

The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation.Semantic proximity Read ↗

Cell Cycle Dysregulation by Human Cytomegalovirus: Influence of the Cell Cycle Phase at the Time of Infection and Effects on Cyclin TranscriptionSemantic proximity Read ↗

The Human Cytomegalovirus IE86 Protein Can Block Cell Cycle Progression after Inducing Transition into the S Phase of Permissive CellsSemantic proximity Read ↗

Cyclin-Dependent Kinase Activity Controls the Onset of the HCMV Lytic CycleSemantic proximity Read ↗

Infection of Cells with Human Cytomegalovirus during S Phase Results in a Blockade to Immediate-Early Gene Expression That Can Be Overcome by Inhibition of the ProteasomeSemantic proximity Read ↗

Manipulation of the cell cycle by human cytomegalovirusSemantic proximity Read ↗

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear LocalizationSemantic proximity Read ↗

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.Semantic proximity Read ↗

Human cytomegalovirus immediate early proteins and cell growth controlSemantic proximity Read ↗

Emerging Mechanisms of G 1 /S Cell Cycle Control by Human and Mouse CytomegalovirusesSemantic proximity Read ↗

The Products of the Herpes Simplex Virus Type 1 Immediate-Early U <sub>S</sub> 1/U <sub>S</sub> 1.5 Genes Downregulate Levels of S-Phase-Specific Cyclins and Facilitate Virus Replication in S-Phase Vero CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.