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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

1 Nov 2023

Abstract excerpt

The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that...

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PMID: 37915066
DOI: 10.1186/s12985-023-02203-y

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