Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Cytomegalovirus 86-Kilodalton IE2 Protein Blocks Cell Cycle Progression in G 1

1 Nov 1999

Abstract excerpt

The 86-kDa IE2 protein of human cytomegalovirus (HCMV) is an important regulator of viral and host cell gene expression. Still, besides its function as a transcription factor, little is known about the biological activities of IE2. Here, we show that IE2 can induce a G(1) arrest in several different cell lines, including HCMV-permissive U-373 cells. The known transcriptional activation domains of IE2 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Cytomegalovirus and herpesvirus research
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10516036
DOI: 10.1128/jvi.73.11.9274-9283.1999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Cytomegalovirus 86-Kilodalton IE2 Protein Blocks Cell Cycle Progression in G 1PMID 10516036Read ↗

Human cytomegalovirus immediate-early over protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cellsSemantic proximity Read ↗

Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.Semantic proximity Read ↗

The Human Cytomegalovirus IE86 Protein Can Block Cell Cycle Progression after Inducing Transition into the S Phase of Permissive CellsSemantic proximity Read ↗

The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation.Semantic proximity Read ↗

Manipulation of the cell cycle by human cytomegalovirusSemantic proximity Read ↗

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein FunctionSemantic proximity Read ↗

The IE2 60-Kilodalton and 40-Kilodalton Proteins Are Dispensable for Human Cytomegalovirus Replication but Are Required for Efficient Delayed Early and Late Gene Expression and Production of Infectious VirusSemantic proximity Read ↗

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.Semantic proximity Read ↗

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to SSemantic proximity Read ↗

Cyclin-Dependent Kinase Activity Controls the Onset of the HCMV Lytic CycleSemantic proximity Read ↗

Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.Semantic proximity Read ↗

Emerging Mechanisms of G 1 /S Cell Cycle Control by Human and Mouse CytomegalovirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.