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Article

The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

Nature genetics - 1 Jan 1995

Wright E, Hargrave M R, Christiansen J, Cooper L, Kun J, Evans T, Gangadharan U, Greenfield A, Koopman P

Abstract excerpt

Mutations in the human SRY-related gene, SOX9, located on chromosome 17, have recently been associated with the sex reversal and skeletal dysmorphology syndrome, campomelic dysplasia. In order to clarify the role of this gene in skeletal development, we have studied the expression of mouse Sox9 during embryogenesis. Sox9 is expressed predominantly in mesenchymal condensations throughout the embryo before and...

Topics

Amino Acid Sequence
Animals
Base Sequence
Bone Diseases, Developmental
Cartilage
Chromosome Mapping
DNA, Complementary
Disease Models, Animal
Disorders of Sex Development
Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation, Developmental

High Mobility Group Proteins

Humans

In Situ Hybridization

Male

Mice

Molecular Sequence Data

Source

Identifiers

PMID: 7704017
DOI: 10.1038/ng0195-15

Genes

SOX9
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7704017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.PMID 7704017Read ↗

<i>Sox9</i> in Testis DeterminationSemantic proximity Read ↗

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.Semantic proximity Read ↗

A male-specific role for <i>SOX9</i> in vertebrate sex determinationSemantic proximity Read ↗

Exclusion of Sox9 as a candidate for the mouse mutant tail-short.Semantic proximity Read ↗

Dominance of SOX9 function over RUNX2 during skeletogenesisSemantic proximity Read ↗

The role of SOX9 in autosomal sex reversal and campomelic dysplasia.Semantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasiaSemantic proximity Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene.Semantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationSemantic proximity Read ↗

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