Article
A model of the cell-autonomous mammalian circadian clock.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009
Mirsky Henry P, Liu Andrew C, Welsh David K, Kay Steve A, Doyle Francis J
Abstract excerpt
Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric characterizing the operation of the clocks. In this study, we built a mathematical model from the...
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