Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system.

doi:10.1016/S0002-9440(10)64435-5

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Article

Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system.

The American journal of pathology - 1 Nov 2002

Konishi Yoshihiro, Lindholm Kristina, Yang Li-Bang, Li Rena, Shen Yong

Abstract excerpt

Isolation and culture of mature neurons from affected brain regions during diseased states provide a well-suited in vitro model system to study age-related neurodegeneration under dynamic conditions at cellular levels. We have developed a novel technique to isolate living neurons from rapidly autopsied human elderly brains, and have succeeded in keeping them alive in vitro. Specifically, the parietal cortex...

Topics

Aged
Brain
Calcium
Cell Survival
Cells, Cultured
DNA
Female
Humans
Immunohistochemistry
Immunomagnetic Separation
Male
Neurons
Neurotransmitter Agents
Phenotype

Source

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Identifiers

PMID: 12414505
DOI: 10.1016/S0002-9440(10)64435-5
PMCID: PMC1850778

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