Article
Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 1994
Rijli F M, Dollé P, Fraulob V, LeMeur M, Chambon P
Abstract excerpt
A neomycin resistance (neo) gene driven by the phosphoglycerokinase (PGK) promoter was inserted into the Hoxd-10 homeobox by homologous recombination in embryonic stem (ES) cells. Chimeric mice derived from ES cell-injected blastocysts died shortly after birth. Craniofacial and axial abnormalitie...
Topics
- Alleles
- Animals
- Bone and Bones
- Cell Line
- Chimera
- Drug Resistance
- Facial Bones
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes, Homeobox
- In Situ Hybridization
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Multigene Family
- Neomycin
- Recombination, Genetic
- Skull