Article
Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects.
Development (Cambridge, England) - 1 Jun 2005
McNulty Claire L, Peres João N, Bardine Nabila, van den Akker Willem M R, Durston Antony J
Abstract excerpt
The Hox paralogous group 1 (PG1) genes are the first and initially most anterior Hox genes expressed in the embryo. In Xenopus, the three PG1 genes, Hoxa1, Hoxb1 and Hoxd1, are expressed in a widely overlapping domain, which includes the region of the future hindbrain and its associated neural crest. We used morpholinos to achieve a complete knockdown of PG1 function. When Hoxa1, Hoxb1 and Hoxd1 are knocked down...
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