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Article

RNA polymerase II transcription in murine cells lacking the TATA binding protein.

Science (New York, N.Y.) - 1 Nov 2002

Martianov Igor, Viville Stephane, Davidson Irwin

Abstract excerpt

Inactivation of the murine TATA binding protein (TBP) gene by homologous recombination leads to growth arrest and apoptosis at the embryonic blastocyst stage. However, after loss of TBP, RNA polymerase II (pol II) remains in a transcriptionally active phosphorylation state, and in situ run-on experiments showed high levels of pol II transcription comparable to those of wild-type cells. In contrast, pol I and pol...

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Source

Identifiers

PMID: 12411709
DOI: 10.1126/science.1076327

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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