Article
The TATA-binding protein as a regulator of cellular transformation.
Cell cycle (Georgetown, Tex.) - 1 Jan 2000
Johnson Sandra A S, Dubeau Louis, White Robert J, Johnson Deborah L
Abstract excerpt
The TATA-binding protein, TBP, is used by all three RNA polymerases and is therefore central to the process of gene expression. TBP associates with several subsets of proteins, called TATA-binding protein-associated factors (TAFs). This results in the formation of at least three distinct complexes, SL1, TFIID, and TFIIIB, which dictates whether TBP functions in RNA polymerase (pol) I, pol II, or pol III...
Topics
- Animals
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Gene Expression Regulation
- Genes, ras
- Humans
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Protein Binding
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- TATA-Binding Protein Associated Factors
- TATA-Box Binding Protein
- Transcription Factor TFIIIB
- Tumor Suppressor Protein p53