High prevalence of the 437G mutation associated with sulfadoxine resistance among Plasmodium falciparum clinical isolates from Iran, three years after the introduction of sulfadoxine-pyrimethamine.

Abstract excerpt

OBJECTIVE: The objective of this study was to determine the frequency of dhfr and dhps resistance-associated haplotypes in Plasmodium falciparum isolates, three years after the introduction of sulfadoxine-pyrimethamine (SP) as the first-line antimalarial treatment in Iran. METHODS: Blood samples (N=182) were collected from patients presenting with falciparum malaria from southeastern Iran, and analyzed by...

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• Antimalarials
• Dihydropteroate Synthase
• Drug Combinations
• Genes, Protozoan