High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon.

Abstract excerpt

OBJECTIVES: The frequency of dhfr and dhps point mutations was assessed in Plasmodium falciparum isolates from pregnant women in Libreville. METHODS: PCR-restriction fragment length polymorphism of polymorphic codons of the dhfr gene (51, 59 and 108) and the dhps gene (436, 437 and 540) was performed in matched peripheral and placental blood samples. RESULTS: The proportion of multiple mutations was high (98%),...

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• Blood
• Dihydropteroate Synthase
• DNA Restriction Enzymes
• Gabon
• Pregnancy Complications, Infectious