Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

1 Jan 2002

Abstract excerpt

The development of genomic instability is an important step in generating the multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes due to gene amplification. One mechanism for gene amplification is the breakage/fusion/bridge (B/F/B) cycle that involves the repeated fusion and breakage of chromosomes following the loss of a telomere. B/F/B cycles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to Genomic variations and chromosomal abnormalities
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12407447
DOI: 10.1038/sj.neo.7900267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell LinePMID 12407447Read ↗

The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.Semantic proximity Read ↗

Telomere dysfunction drives chromosomal instability in human mammary epithelial cellsSemantic proximity Read ↗

Chromosome rearrangements resulting from telomere dysfunction and their role in cancerSemantic proximity Read ↗

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumorsSemantic proximity Read ↗

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene AmplificationSemantic proximity Read ↗

Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies.Semantic proximity Read ↗

Analysis of alternative lengthening of telomere markers in BRCA1 defective cells.Semantic proximity Read ↗

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid CellsSemantic proximity Read ↗

The Relationship Between Spontaneous Telomere Loss and Chromosome Instability in a Human Tumor Cell LineSemantic proximity Read ↗

Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines.Semantic proximity Read ↗

Discrete DNA integration events during Bridge-Induced Translocation generate partial chromosomal deletions and differential aneuploidy in Saccharomyces cerevisiaeSemantic proximity Read ↗

Dysfunctional telomeres in human BRCA2 mutated breast tumors and cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.