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Article

Analysis of alternative lengthening of telomere markers in BRCA1 defective cells.

Genes, chromosomes & cancer - 1 Nov 2016

Kargaran Parisa K, Yasaei Hemad, Anjomani-Virmouni Sara, Mangiapane Giovanna, Slijepcevic Predrag

Abstract excerpt

Telomeres are specialized structures responsible for the chromosome end protection. Previous studies have revealed that defective BRCA1 may lead to elevated telomere fusions and accelerated telomere shortening. In addition, BRCA1 associates with promyelocytic leukemia (PML) bodies in alternative lengthening of telomeres (ALTs) positive cells. We report here elevated recombination rates at telomeres in cells from...

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Share to BRCA1 Protein
Share to Cell Line, Tumor
Share to Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mouse Embryonic Stem Cells

Share to Recombination, Genetic

Share to Telomerase

Share to Telomere

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 27295426
DOI: 10.1002/gcc.22386
PMCID: PMC5113789

Genes

BRCA1
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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