Article
Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies.
Cancer biology & therapy - 1 Jan 2000
Montgomery Elizabeth, Wilentz Robb E, Argani Pedram, Fisher Cyril, Hruban Ralph H, Kern Scott E, Lengauer Christoph
Abstract excerpt
A classification of neoplasms as chromosomally stable vs. unstable is of importance in assessing inherited risks but is primarily defined in cell lines where rates of instability can be directly measured. The confirmation of such a mechanistic theory in primary tissues is desirable. We examined anaphase figures in histologic slides to evaluate such criteria. The process of chromosomal instability (CIN) involves...
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