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Article

Characterization of high-altitude pulmonary hypertension in the Kyrgyz: association with angiotensin-converting enzyme genotype.

American journal of respiratory and critical care medicine - 15 Nov 2002

Aldashev Almaz A, Sarybaev Akpay S, Sydykov Akyl S, Kalmyrzaev Bolot B, Kim Elena V, Mamanova Lira B, Maripov Rashid, Kojonazarov Baktybek K, Mirrakhimov Mirsaid M, Wilkins Martin R, Morrell Nicholas W

Abstract excerpt

Previous studies have suggested a genetic component in susceptibility to hypoxia-induced pulmonary hypertension. We therefore estimated the prevalence of high-altitude pulmonary hypertension (HAPH) in a Kyrgyz population and whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene associates with HAPH. An electrocardiographic survey of 741 highlanders demonstrated...

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Identifiers

PMID: 12406857
DOI: 10.1164/rccm.200204-345OC

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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