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Article

Polymorphisms of renin-angiotensin system genes with high-altitude pulmonary edema in Japanese subjects.

Chest - 1 Sept 2004

Hotta Junichi, Hanaoka Masayuki, Droma Yunden, Katsuyama Yoshihiko, Ota Masao, Kobayashi Toshio

Abstract excerpt

STUDY OBJECTIVES: The renin-angiotensin system (RAS), including angiotensin-converting enzyme (ACE) and angiotensin II type 1 receptor (AT(1)R), plays an important role in the pathogenesis of pulmonary hypertension, which is suggested to be critical in the development of high-altitude pulmonary edema (HAPE). Investigating the associations of the polymorphisms in the genes of RAS with HAPE is to elucidate the...

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Source

Identifiers

PMID: 15364762
DOI: 10.1378/chest.126.3.825

Genes

ACE
PVR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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