Article
No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.
European journal of clinical investigation - 1 Oct 2002
Van Aken M O, De Craen A J M, Gussekloo J, Moghaddam P Hanifi, Vandenbroucke J P, Heijmans B T, Slagboom P E, Westendorp R G J
Abstract excerpt
BACKGROUND: The C282Y mutation in the gene for haemochromatosis (HFE) has been associated with various diseases at middle age. However, recent studies indicate that penetrance of the C282Y mutation is low. We explored the association between the C282Y mutation, iron metabolism, and morbidity and mortality in participants of the Leiden 85-plus. STUDY DESIGN: A cross-sectional comparison and prospective follow-up...
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