HFE Mutations as risk factors in disease.

Abstract excerpt

Iron deficiency is the most common disorder of iron metabolism worldwide, but there is concern that iron accumulation resulting from enhanced iron absorption may also be a cause of morbidity. In patients with genetic haemochromatosis the clinical manifestations of iron overload are well-known. In northern Europe 90% of such patients are homozygous for the C282Y mutation of the HFE gene and this genotype is found...

Topics

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• Gene Frequency
• Genotype
• Hemochromatosis Protein
• Histocompatibility Antigens Class I
• Iron Metabolism Disorders