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Article

HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening study.

Circulation. Cardiovascular genetics - 1 Feb 2009

Adams Paul C, Pankow James S, Barton James C, Acton Ron T, Leiendecker-Foster Cathie, McLaren Gordon D, Speechley Mark, Eckfeldt John H

Abstract excerpt

BACKGROUND: Previous studies have suggested a positive association of coronary heart disease risk and both serum ferritin concentrations and C282Y heterozygosity. Relationships between serum lipids, C282Y homozygosity, and serum ferritin have not been well established. METHODS AND RESULTS: The He...

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Source

Identifiers

PMID: 20031565
DOI: 10.1161/CIRCGENETICS.108.813089

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20031565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening study.PMID 20031565Read ↗

HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study.Semantic proximity Read ↗

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Clinical characteristics of HFE C282Y/H63D compound heterozygotes identified in a specialty practice: key differences from HFE C282Y homozygotes.Semantic proximity Read ↗

Nonexpressing homozygotes for C282Y hemochromatosis: minority or majority of cases?Semantic proximity Read ↗

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No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.Semantic proximity Read ↗

Platelet counts in HFE p.C282Y/p.C282Y and wt/wt post-screening clinical evaluation participants.Semantic proximity Read ↗

HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level <1000 µg/L.Semantic proximity Read ↗

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