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Article

Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women.

Circulation - 21 Sept 1999

Roest M, van der Schouw Y T, de Valk B, Marx J J, Tempelman M J, de Groot P G, Sixma J J, Banga J D

Abstract excerpt

Background-The genetic background of hereditary hemochromatosis (HH) is homozygosity for a cysteine-to-tyrosine transition at position 282 in the HFE gene. Heterozygosity for HH is associated with moderately increased iron levels and could be a risk factor for cardiovascular death. Methods and Results-We studied the relation between HH heterozygosity and cardiovascular death in a cohort study among 12 239 women...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10491369
DOI: 10.1161/01.cir.100.12.1268

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women.PMID 10491369Read ↗

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.Semantic proximity Read ↗

Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland.Semantic proximity Read ↗

Association studies between haemochromatosis gene mutations and the risk of cardiovascular diseases.Semantic proximity Read ↗

Hereditary hemochromatosis with homozygous C282Y HFE mutation: possible clinical model to assess effects of elevated reactive oxygen species on the development of cardiovascular disease.Semantic proximity Read ↗

C282Y Homozygosity Increases Erythrocyte Turnover and Decreases HbA1c-A Population-Based Study.Semantic proximity Read ↗

Mutations in the hemochromatosis gene (HFE) and stroke.Semantic proximity Read ↗

Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects.Semantic proximity Read ↗

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[Prevalence of hemochromatosis-associated mutations in the hemochromatosis gene in the Danish population].Semantic proximity Read ↗

Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study.Semantic proximity Read ↗

A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study.Semantic proximity Read ↗

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