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Article

Rapid development of colitis in NSAID-treated IL-10-deficient mice.

Gastroenterology - 1 Nov 2002

Berg Daniel J, Zhang Juan, Weinstock Joel V, Ismail Hanan F, Earle Keith A, Alila Hector, Pamukcu Rifat, Moore Steven, Lynch Richard G

Abstract excerpt

BACKGROUND & AIMS: Interleukin (IL)-10 is an anti-inflammatory and immune regulatory cytokine. IL-10-deficient mice (IL-10(-/-)) develop chronic inflammatory bowel disease (IBD), indicating that endogenous IL-10 is a central regulator of the mucosal immune response. Prostaglandins are lipid mediators that may be important mediators of intestinal inflammation. In this study we assessed the role of prostaglandins...

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Identifiers

PMID: 12404228
DOI: 10.1053/gast.2002.1231527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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