Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice.

The Journal of laboratory and clinical medicine - 1 Oct 1999

Yang F, de Villiers W J, Lee E Y, McClain C J, Varilek G W

Abstract excerpt

Recent studies support nuclear factor-kappaB (NF-kappaB) as a critical transcription factor in inflammatory bowel disease. We examined NF-kappaB and its inhibitors, IkappaB-alpha and IkappaB-beta, in the colitis of interleukin-2 deficient (IL-2-/-) mice at the ages of 5, 10, and 15 weeks and compared them with those of age-matched wild-type mice. Colon levels of nuclear NF-kappaB and mRNA for NF-kappaB responsive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis, Ulcerative
Share to Cytosol
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1

Share to Interleukin-10

Share to Interleukin-2

Share to Mice, Mutant Strains

Share to NF-kappa B

Source

Identifiers

PMID: 10521084
DOI: 10.1016/s0022-2143(99)90152-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice.PMID 10521084Read ↗

NF‐κB SignalingSemantic proximity Read ↗

Role of NF-κB in immune and inflammatory responses in the gutSemantic proximity Read ↗

Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.Semantic proximity Read ↗

Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2.Semantic proximity Read ↗

Rapid development of colitis in NSAID-treated IL-10-deficient mice.Semantic proximity Read ↗

Interleukin-10-deficient mice develop chronic enterocolitis.Semantic proximity Read ↗

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.Semantic proximity Read ↗

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.Semantic proximity Read ↗

Typhlocolitis in NF-kappa B-deficient mice.Semantic proximity Read ↗

Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis.Semantic proximity Read ↗

Aging in the absence of TLR2 is associated with reduced IFN-gamma responses in the large intestine and increased severity of induced colitis.Semantic proximity Read ↗

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.