Article
Interleukin-19 protects mice from innate-mediated colonic inflammation.
Inflammatory bowel diseases - 1 Jun 2010
Azuma Yasu-Taka, Matsuo Yukiko, Kuwamura Mitsuru, Yancopoulos George D, Valenzuela David M, Murphy Andrew J, Nakajima Hidemitsu, Karow Margaret, Takeuchi Tadayoshi
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) results from the chronic dysregulation of the mucosal immune system and the aberrant activation of both the innate and the adaptive immune responses. We used two complementary models of colonic inflammation to examine the roles of interleukin (IL)-19 in colonic inflammation and thus its possible role in IBD. METHODS: Using gene-targeting, we generated IL-19-deficient...
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