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Article

Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.

The Journal of infectious diseases - 15 Nov 2002

Agnese Doreen M, Calvano Jacqueline E, Hahm Sae J, Coyle Susette M, Corbett Siobhan A, Calvano Steve E, Lowry Stephen F

Abstract excerpt

Human toll-like receptor 4 (hTLR4) and CD14 are known to be components of the lipopolysaccharide receptor complex. Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for s...

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Source

Identifiers

PMID: 12404174
DOI: 10.1086/344893

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12404174-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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