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Article

Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.

Immunology - 1 Jul 2003

Feterowski Carolin, Emmanuilidis Klaus, Miethke Thomas, Gerauer Klaus, Rump Martina, Ulm Kurt, Holzmann Bernhard, Weighardt Heike

Abstract excerpt

Genetically determined responsiveness to microbial stimuli such as lipopolysaccharide (LPS) may affect the pathophysiology of human sepsis. The D299G mutation in human Toll-like receptor-4 (TLR4) impairs LPS signalling in homozygous and heterozygous individuals. To investigate whether the presenc...

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Source

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Identifiers

PMID: 12807489
DOI: 10.1046/j.1365-2567.2003.01674.x
PMCID: PMC1782987

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12807489-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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