Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.

Immunology - 1 Jul 2003

Feterowski Carolin, Emmanuilidis Klaus, Miethke Thomas, Gerauer Klaus, Rump Martina, Ulm Kurt, Holzmann Bernhard, Weighardt Heike

Abstract excerpt

Genetically determined responsiveness to microbial stimuli such as lipopolysaccharide (LPS) may affect the pathophysiology of human sepsis. The D299G mutation in human Toll-like receptor-4 (TLR4) impairs LPS signalling in homozygous and heterozygous individuals. To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Membrane Glycoproteins
Share to Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peritonitis

Share to Postoperative Complications

Share to Receptors, Cell Surface

Share to Sepsis

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 12807489
DOI: 10.1046/j.1365-2567.2003.01674.x
PMCID: PMC1782987

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.PMID 12807489Read ↗

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock.Semantic proximity Read ↗

Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis.Semantic proximity Read ↗

Association of TLR4 polymorphisms (Asp299Gly and Thr399Ile) with sepsis: a meta-analysis and trial sequence analysis.Semantic proximity Read ↗

The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.Semantic proximity Read ↗

The TLR4 +896 polymorphism is not associated with lipopolysaccharide hypo-responsiveness in leukocytes.Semantic proximity Read ↗

TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.Semantic proximity Read ↗

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.Semantic proximity Read ↗

Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.Semantic proximity Read ↗

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.Semantic proximity Read ↗

Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and/or pneumonia.Semantic proximity Read ↗

Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients.Semantic proximity Read ↗

Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.