Article
Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.
The Journal of biological chemistry - 10 Nov 2006
Nagy Gyorgy, Ward Jeffrey, Mosser Dick D, Koncz Agnes, Gergely Peter, Stancato Christina, Qian Yueming, Fernandez David, Niland Brian, Grossman Craig E, Telarico Tiffany, Banki Katalin, Perl Andras
Abstract excerpt
A novel 2986-base transcript encoded by the antisense strand of the HRES-1 human endogenous retrovirus was isolated from peripheral blood lymphocytes. This transcript codes for a 218-amino acid protein, termed HRES-1/Rab4, based on homology to the Rab4 family of small GTPases. Antibody 13407 raised against recombinant HRES-1/Rab4 detected a native protein of identical molecular weight in human T cells. HRES-1...
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