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Article

Altered Na+/H+ exchanger isoform 1 activity in immortalized lymphoblasts from women with pre-eclampsia: evidence for an intermediate phenotype.

Clinical science (London, England : 1979) - 1 Nov 2002

Lee V M, Quinn P A, Jennings S C, Halligan A W F, Ng L L

Abstract excerpt

Previous studies have demonstrated a raised Na(+) content in leucocytes isolated from women with pre-eclampsia. Increased Na(+)/H(+) exchanger activity is one membrane transport abnormality that may contribute to this phenomenon and may be implicated in the abnormal volume homoeostasis and hypertension associated with the disease. Increased Na(+)/H(+) exchanger activity has been documented in nucleated white...

Topics

Adult
Blotting, Western
Cell Culture Techniques
Cell Transformation, Viral
Female
Genetic Predisposition to Disease
Humans
Hydrogen-Ion Concentration
Lymphocytes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pre-Eclampsia

Pregnancy

Sodium-Hydrogen Exchangers

Source

Identifiers

PMID: 12401124
DOI: 10.1042/cs1030503

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