Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective.

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Article

Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective.

The Journal of biological chemistry - 6 May 1994

Wakabayashi S, Bertrand B, Ikeda T, Pouysségur J, Shigekawa M

Abstract excerpt

The ubiquitous plasma membrane Na+/H+ exchanger (NHE1) is rapidly activated in response to various extracellular signals. To understand how the intracellular Ca2+ is involved in this activation process, we investigated the effect of Ca2+ ionophore ionomycin on activity of the wild-type or mutant...

Topics

Binding Sites
Calcium
Calmodulin
Calmodulin-Binding Proteins
Cell Size
Cells, Cultured
Humans
Hydrogen
Hydrogen-Ion Concentration
Ionomycin
Mutation
Phosphorylation
Sodium
Sodium-Hydrogen Exchangers
Thrombin

Source

Open in PubMed

Identifiers

PMID: 8175807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8175807-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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