Article
Na(+)-H+ antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 May 1995
Ng L L, Sweeney F P, Siczkowski M, Davies J E, Quinn P A, Krolewski B, Krolewski A S
Abstract excerpt
Previous studies have demonstrated an elevated Na(+)-H+ exchanger activity in various cell types from patients with essential hypertension. The phenotype of an increased maximal transport capacity is preserved in Epstein-Barr virus immortalized lymphoblasts from hypertensive patients. The mechanisms underlying this abnormality are unclear. In this study, we used lymphoblasts from hypertensive patients and...
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