Article
Abnormal Na+/H+ antiporter phenotype and turnover of immortalized lymphoblasts from type 1 diabetic patients with nephropathy.
The Journal of clinical investigation - 1 Jun 1994
Ng L L, Davies J E, Siczkowski M, Sweeney F P, Quinn P A, Krolewski B, Krolewski A S
Abstract excerpt
Cellular Na+/H+ exchanger (NHE) activity is elevated in type 1 diabetic patients with nephropathy and patients with essential hypertension. The characteristics of this NHE phenotype in hypertension (raised Vmax and a lowered Hill coefficient) are preserved in Epstein-Barr virus-transformed lympho...
Topics
- Adult
- Cells, Cultured
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Female
- Humans
- Hydrogen-Ion Concentration
- Lymphocyte Activation
- Lymphocytes
- Male
- Phenotype
- Sodium-Hydrogen Exchangers