Article
Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe.
The American journal of physiology - 1 Sept 1998
McSwine R L, Musch M W, Bookstein C, Xie Y, Rao M, Chang E B
Abstract excerpt
We examined the regulation of the Na+/H+ exchangers (NHEs) NHE2 and NHE3 by expressing them in human intestinal C2/bbe cells, which spontaneously differentiate and have little basal apical NHE activity. Unidirectional apical membrane 22Na+ influxes were measured in NHE2-transfected (C2N2) and NHE...
Topics
- Amiloride
- Cell Line
- Cell Membrane
- Cyclic AMP
- Cyclic GMP
- Guanidines
- Humans
- Intestinal Mucosa
- Kinetics
- Phenotype
- Recombinant Proteins
- Second Messenger Systems
- Sodium
- Sodium-Hydrogen Exchanger 3
- Sodium-Hydrogen Exchangers
- Sulfones
- Tetradecanoylphorbol Acetate
- Thapsigargin