Article
Increased Na(+)/H(+) exchanger isoform 1 activity in spontaneously hypertensive rats: lack of mutations within the coding region of NHE1.
Biochimica et biophysica acta - 21 Feb 2000
Orlov S N, Adarichev V A, Devlin A M, Maximova N V, Sun Y L, Tremblay J, Dominiczak A F, Postnov Y V, Hamet P
Abstract excerpt
Enhanced Na(+)/H(+) exchange, measured as amiloride derivative-sensitive Na(+) and H(+) fluxes in cells with a preliminary acidified cytoplasm (Deltamu(H+)-induced Na(+)/H(+) exchange), is one of the most prominent intermediate phenotypes of altered vascular smooth muscle cell (VSMC) function in spontaneously hypertensive rats (SHR). Analysis of Na(+)/H(+) exchange in F(2) hybrids of SHR and normotensive rats...
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